Analysis of the ZNT8, GAD65, HLA-DQA1, HLA-DQB1, and C-peptides in Indonesian children with type 1 diabetes mellitus

Autoimmune reaction in Type 1 Diabetes Mellitus (T1DM) is caused by genetic and environmental factors. The genes HLA-DQA1 HLA-DQB1 are strongly associated with T1DM. Other established markers of T1DM were Zinc Transporter 8 Antibody (ZnT8), Glutamic Acid Decarboxylase Antibody-65 (GAD65), C-peptide. This study aims to analyze ZnT8, GAD65, HLA-DQA1, HLA-DQB1, C-peptide Indonesian children A cross-sectional was conducted Dr. Soetomo Hospital, Indonesia. examined an ELISA kit. Mann-Whitney test performed a significant value p<0.05. total 62 participants consisting 31 for each group enrolled. prevalence patients 77.4%, 90.3%, 87.1%. There 74% had two positive antibodies 55% HLA peptides. no difference peptides between control groups (p=0.12; p=0.19). Meanwhile, the comparison C-Peptide values shows (p<0.05). peptide higher non-T1DM children.